Overview
A chronic inflammatory condition associated with linear grey-white retinal lesions located in the macula or juxtapapillary retina and associated with chorioretinal atrophy. It most commonly affects men aged 30-70 years.
This condition is associated with blurred vision, metamorphopsia, photopsia and paracentral scotomas.
When lesions are active, subretinal fluid is typically noted and lesions have a hyper-fluorescent border on fundus autofluorescence imaging. In the active stage, OCT shows hyper-reflectivity of the RPE, ellipsoid zone and outer nuclear layer (ONL).
Over time, as chorioretinal atrophy develops, these lesions become more hypo-fluorescent and the outer retinal layers atrophy. Increased signal transmission through to the choroid is noted.
Choroidal neovascularisation is a potential sequelae of this condition.
Differential Diagnosis
References
Knickelbein, JE. Nida Sen, H. (2016) Multimodal Imaging of the White Dot Syndromes and Related Diseases J Clin Exp Ophthalmol. 2016 June ; 7(3): .
Wong, E. Nivison-Smith, L. Assaad, NN. Kalloniatis, M. (2015). OCT and fundus autofluorescence enhances visualization of white dot syndromes. Optometry and Vision Science, 92(5):642-53.